Biochemical Practice

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Biochemical markers in osteoporosis: usefulness in clinical practice.

Currently, the measurement of bone remodeling biomarkers is an innovate proposal in clinical evaluation of patients with osteoporosis. Its use may identify patients at increased risk of fracture as well as monitoring therapeutic efficacy. Because they constitute a relatively inexpensive non-invasive measurement, its use should be widespread for serial and frequent measurements of bone turnover....

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In a previous paper the case history was given of a 10-year-old boy admitted to hospital for a psychotic illness associated with a photosensitive skin rash (Hersov, 1955). The condition resembled classical pellagra, and although no dietary reason for a vitamin deficiency was apparent, a good response was obtained to treatment with nicotinamide. Biochemical investigations revealed gross and pers...

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Biochemical markers of bone turnover: why theory, research, and clinical practice are still in conflict.

In metabolic bone diseases other than osteoporosis (Paget disease, rickets and osteomalacia, primary and secondary hyperparathyroidism), biochemical markers of bone turnover have been important clinical tools in patient management for more than 3 decades. In these diseases, bone metabolism is often so abnormal that even crude, nonspecific markers such as total serum alkaline phosphatase and uri...

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ژورنال

عنوان ژورنال: Nature

سال: 1960

ISSN: 0028-0836,1476-4687

DOI: 10.1038/185797b0